Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis
نویسندگان
چکیده
منابع مشابه
Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis
Various pathophysiologic mechanisms leading to sickness behaviors have been proposed. For example, an inflammatory process in the hypothalamus has been implicated, but the signaling modalities that involve inflammatory mechanisms and neuronal circuit functions are ill-defined. Here, we show that toll-like receptor 2 (TLR2) activation by intracerebroventricular injection of its ligand, Pam3CSK4,...
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1 Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA 2Children’s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA 3Department of Neurobiology, Zhejiang University School of Medicine, 866 Yu Hang Tang Road, Hangzhou, Zhejiang 310058, China 4Department of Psychiatry, University of British Columbia, 2211 Wesbrook Mall, Vanc...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep29424